MRC Postdoctoral Research Scientist

MRC Postdoctoral Research Scientist

Salary: £41,344 plus London allowances £5,385 per annum*

Fixed term (3 Years)

London, UK

About us

The MRC Laboratory of Medical Sciences (LMS) is a biomedical research institute where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. LMS is one of three directly funded MRC research institutes and enjoys close links with our partners at Imperial College London and at the Imperial College Healthcare NHS Trust.

About the role

We are seeking an experienced Postdoctoral Research Scientist, Structural Biologist, who will be responsible for investigating the structural mechanism of ATP-dependent chromatin remodelling complexes. The post holder will join an internationally-leading team of scientists in the Single-Molecule Biophysics Group using world-class single-molecule facilities and will work closely with collaborating research groups and industry partners. In addition, the post-holder will be responsible for conducting the expression and purification of ATP-dependent chromatin remodelling enzymes, sample preparation for cryo-electron microscopy experiments, cryo-electron microscopy imaging and data analysis, model building, interoperating structural data to elucidate biological mechanisms, obtaining high-quality data, and supporting and training other lab members.

About You

You will need a PhD and be able to demonstrate extensive and direct practical experience in cryo-electron microscopy sample preparation, data processing and model building, with a strong track record of publications and presentations at meetings. You will have proven ability in structural biology and biochemistry, and have applied structural and biochemical based techniques to cutting-edge biological problems. Extensive experience in single-particle cryo-electron microscopy, biochemical techniques, the use of insect-cell based expression systems, and purification of multi-subunit protein complexes are essential. Additionally, experience working in protein-DNA interactions is essential. While experience with working with ATP-dependent chromatin remodelling enzymes is desirable. Previous experience with collaborating with single-molecule biophysicist to produce a strong track record of publications is also desirable.

What we offer

As well as the exciting opportunities this role presents, we also offer defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits

How to apply

For full details of this post and to complete an online application, please visit and upload your CV, names and contacts of two scientific references along with a cover letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be accepted. Please quote reference number 2711.

Closing date: 24 September

Please note that applications may be reviewed by both LMS and Imperial staff

*Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two and £1,800 in the third year.