Research Associate in MND Genetics - Strand, London, WC2R 2LS

Research Associate in MND Genetics - Strand, London, WC2R 2LS

About us:

The post sits within the UK MND Research Institute in the Department of Basic and Clinical Neuroscience at Kings College London, and forms part of Workstream 3 in the NIHR Biomedical Research Centre and charity funded EXPERTS-ALS experimental medicines platform. EXPERTS-ALS is an innovative clinical trial designed to rapidly test multiple potential treatments for motor neuron disease (also known as amyotrophic lateral sclerosis, ALS, MND). The MND research team at Kings has been active since the 1990s and has been recognised by multiple international awards. It is closely integrated with the clinical service, Biomedical Research Centre and Dementia Research Institute, offering a full range of research from discovery science through to late-stage clinical trials.

About the role:

The post-holder will carry out genomic analyses of samples from the EXPERTS-ALS programme as well as other research collections, integrating findings with clinical data, epigenetic results, transcriptomics, and proteomics. They will work closely with other members of the MND research group, including both wet-lab and bioinformatics teams, to generate, analyse and interpret research findings. The post-holder will work closely with Dr Ahmad Al Khleifat and report to Professor Ammar Al-Chalabi, Director of the Kings MND Care and Research Centre, while providing updates to the NIHR Maudsley Biomedical Research Centre as required.

The successful applicant will be expected to present their findings at national and international conferences and meetings, and to publish in peer reviewed journals.

This is a full-time post (35 hours per week), and you will be offered a fixed term contract until 31/03/2028.

Research staff at Kings are entitled to at least 10 days per year (pro-rata) for professional development. This entitlement, from the Concordat to Support the Career Development of Researchers , applies to Postdocs, Research Assistants, Research and Teaching Technicians, Teaching Fellows and AEP equivalent up to and including grade 7. Visit the Centre for Research Staff Development for more information.

About you:

To be successful in this role, we are looking for candidates to have the following skills and experience:

Essential criteria

1. PhD or equivalent experience in a relevant subject area ( e.g. bioinformatics, and Genetics) . *
2. Up to date knowledge of NGS pipelines
3. Experience working with large-scale DNA sequencing datasets
4. Developed and applied innovative research methods, using creativity to analyse and interpret data.
5. Experience in analysing clinical samples to identify genomic markers associated with disease risk, phenotype, and treatment response.
6. Proficient in Unix based systems and programming in at least one language (Python, Java, Bash, Perl, R)
7. Proven experience supervising students in genetics, guiding their academic progress and research skill development.
8. Publication records commensurate with grade

Desirable criteria

1. Ability to carry out statistical analysis of genetic data
2. Up to date knowledge of machine learning methods applied to clinical and omics data
3. Experience in the analysis of epigenetic and transcriptomic data.

Downloading a copy of our Job Description

Full details of the role and the skills, knowledge and experience required can be found in the Job Description document, provided at the bottom of the page. This document will provide information of what criteria will be assessed at each stage of the recruitment process.

* Please note that this is a PhD level role but candidates who have submitted their thesis and are awaiting award of their PhDs will be considered. In these circumstances the appointment will be made at Grade 5, spine point 30 with the title of Research Assistant. Upon confirmation of the award of the PhD, the job title will become Research Associate and the salary will increase to Grade 6.